Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | Q9HBH1 | 1/20 | 0.38 | |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19209361 | 0.91 | HTR2A (0.55) | HTR2AALDH1A1MAPK1L3MBTL1TGM2 | |
| SCHEMBL16599524 | 0.85 | HTR2A (0.52) | HTR2AALDH1A1MAPK1L3MBTL1TGM2 | |
| SCHEMBL19209358 | 0.81 | HTR2A (0.55) | HTR2AALDH1A1MAPK1L3MBTL1PDF | |
| SCHEMBL12477118 | 0.80 | HTR2A (0.58) | HTR2AALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL15676014 | 0.79 | HTR2A (0.55) | HTR2AALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL15810831 | 0.79 | LTA4H (0.57) | HTR2AALDH1A1MAPK1L3MBTL1PDF | |
| SCHEMBL12476680 | 0.79 | HTR2A (0.45) | HTR2AALDH1A1MAPK1L3MBTL1PDF | |
| SCHEMBL20184616 | 0.78 | PDF (0.53) | HTR2AALDH1A1MAPK1L3MBTL1TGM2 | |
| SCHEMBL18941468 | 0.77 | PDF (0.48) | HTR2AALDH1A1MAPK1L3MBTL1PDF | |
| SCHEMBL18941467 | 0.77 | PDF (0.48) | HTR2AALDH1A1MAPK1L3MBTL1PDF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | PFIZER INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20180362519-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2018-12-20 | — | — | US | disclosed |
| EP-3327027-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2018-05-30 | — | — | EP | disclosed |
| EP-3215513-A1 | FUNCTIONALIZED MORPHOLINYL ANTHRACYCLINE DERIVATIVES | Nerviano Medical Sciences S.r.l. (IT) | 2017-09-13 | — | — | EP | disclosed |
| EP-3185908-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | Pfizer Inc (US) | 2017-07-05 | — | — | EP | disclosed |
| EP-3049420-A1 | THIENO[2,3-e]INDOLE DERIVATIVES AS NEW ANTITUMOR AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2016-08-03 | — | — | EP | disclosed |
| WO-2016071418-A1 | FUNCTIONALIZED MORPHOLINYL ANTHRACYCLINE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-12 | — | — | WO | disclosed |
| WO-2016030791-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2016-03-03 | — | — | WO | disclosed |
| WO-2015044003-A1 | THIENO[2,3-e]INDOLE DERIVATIVES AS NEW ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362519-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | NGLY1, TEK, TEKT1 | HTR2A 3851/4885ALDH1A1 4715/4885MAPK1 3409/4885 |
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | NGLY1, TEK, TEKT1 | HTR2A 3851/4885ALDH1A1 4715/4885MAPK1 3409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.