Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 10/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 9/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.43 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921363 | 0.93 | CHEK1 (0.50) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1922389 | 0.85 | ABCG2 (0.41) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921689 | 0.83 | IP6K1 (0.48) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1922920 | 0.81 | MPO (0.42) | MEN1HPGDKMT2AKHK | |
| SCHEMBL1921732 | 0.80 | CSNK2A2 (0.39) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1920560 | 0.77 | TLR7 (0.42) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921690 | 0.77 | ELANE (0.34) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1923158 | 0.75 | CHEK1 (0.47) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL13984750 | 0.73 | CDK8 (0.38) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921349 | 0.73 | CHEK1 (0.45) | CHEK1AURKACSNK1A1CDK8NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170833-B1 | A TRANSITION METAL CATALYZED SYNTHESIS OF 2H-INDAZOLES | SANOFI AVENTIS (FR) | 2011-06-01 | — | — | EP | claimed |