Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PPM1D | O15297 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | KHK | P50053 | 3/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923158 | 0.95 | CHEK1 (0.47) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921732 | 0.86 | CSNK2A2 (0.39) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL12533937 | 0.85 | NPC1 (0.44) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921322 | 0.85 | ALDH1A1 (0.39) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921407 | 0.81 | KCNJ6 (0.39) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16499092 | 0.80 | CHEK1 (0.48) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921363 | 0.79 | CHEK1 (0.50) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16498257 | 0.79 | CHEK1 (0.47) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL17129942 | 0.73 | CHEK1 (0.62) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1920962 | 0.73 | CHEK1 (0.43) | CHEK1AURKACSNK1A1CDK8NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170833-B1 | A TRANSITION METAL CATALYZED SYNTHESIS OF 2H-INDAZOLES | SANOFI AVENTIS (FR) | 2011-06-01 | — | — | EP | claimed |