SCHEMBL19209854

SCHEMBL19209854

CC(C)c1nn(C)c2ncc(-c3nc(Nc4ccc(CN5CCN(C)CC5)cn4)ncc3F)cc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK6 Q00534 18/20 0.64
CDK4 P11802 7/20 0.64
CCND1 P24385 6/20 0.64
CCND3 P30281 8/20 0.56
CCNE2 O96020 3/20 0.56
CDK2 P24941 3/20 0.56
CDK1 P06493 4/20 0.55
CCNA2 P20248 2/20 0.55
DYRK2 Q92630 3/20 0.54
CIT O14578 1/20 0.52
GAK O14976 1/20 0.52
DYRK3 O43781 1/20 0.52
CCNT1 O60563 1/20 0.52
STK16 O75716 1/20 0.52
CCNK O75909 1/20 0.52
STK10 O94804 1/20 0.52
PRKD3 O94806 1/20 0.52
ABCB11 O95342 1/20 0.52
MAP4K4 O95819 1/20 0.52
EGFR P00533 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19209855 0.94 CDK6 (0.72) CDK6CDK4CCND1CCND3CCNE2
SCHEMBL19209858 0.86 CDK6 (0.73) CDK6CDK4CCND1CCND3CCNE2
SCHEMBL22313803 0.83 CDK6 (0.89) CDK6CDK4CCND1CCND3CDK2
SCHEMBL19209812 0.81 CDK6 (0.57) CDK6CDK4CCND1CCND3CCNE2
SCHEMBL19209843 0.80 CDK6 (0.81) CDK6CDK4CCND1CCND3CCNE2
SCHEMBL19231688 0.80 CDK6 (0.67) CDK6CDK4CCND1CCND3CCNE2
SCHEMBL19209848 0.78 CDK6 (0.68) CDK6CDK4CCND1CCND3CDK2
SCHEMBL19231827 0.78 CDK6 (0.64) CDK6CDK4CCND1CCND3CCNE2
SCHEMBL19231690 0.78 CDK6 (0.66) CDK6CDK4CCND1CCND3CCNE2
SCHEMBL19209863 0.78 CDK6 (0.70) CDK6CDK4CCND1CCND3CCNE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017133701-A1 CERTAIN PROTEIN KINASE INHIBITORS SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) 2017-08-10 WO claimed
CN-108602799-B Kinase inhibitor 上海复尚慧创医药研究有限公司 2021-08-03 CN disclosed
WO-2017133701-A1 CERTAIN PROTEIN KINASE INHIBITORS SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) 2017-08-10 WO disclosed
WO-2017133701-A1 CERTAIN PROTEIN KINASE INHIBITORS SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) 2017-08-10 WO disclosed