Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | FABP7 | O15540 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19209925 | 0.78 | DHFR (0.65) | DHFR | |
| SCHEMBL28058221 | 0.73 | BACE1 (0.46) | BACE1KCNH2PIK3CAMTORPIK3CD | |
| SCHEMBL30072245 | 0.70 | FABP7 (0.45) | BACE1KCNH2PIK3CAPIK3CDMAPK14 | |
| SCHEMBL1570328 | 0.70 | FABP7 (0.45) | BACE1KCNH2PIK3CAPIK3CDMAPK14 | |
| SCHEMBL932928 | 0.68 | PIK3CD (0.45) | PIK3CAPIK3CDMAPK14FABP7DYRK1A | |
| SCHEMBL18857842 | 0.67 | MAPK14 (0.47) | PIK3CAMTORPIK3CDMAPK14FABP7 | |
| SCHEMBL29415412 | 0.66 | DHFR (0.58) | DHFRHTR1AHTR7 | |
| SCHEMBL27523614 | 0.66 | MAPT (0.53) | DHFRKCNH2 | |
| SCHEMBL29387046 | 0.64 | HTR7 (0.69) | DHFRHTR1AHTR7 | |
| SCHEMBL15577956 | 0.64 | HTR7 (0.69) | DHFRHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411367-A1 | COMPOSITIONS AND METHODS FOR TREATING INFECTIONS | Vyera Pharmaceuticals, LLC (US) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017136556-A1 | COMPOSITIONS AND METHODS FOR TREATING INFECTIONS | TURING PHARMACEUTICALS LLC (US) | 2017-08-10 | — | — | WO | disclosed |