Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | ME2 | P23368 | 1/20 | 0.43 |
| ▸ | ME1 | P48163 | 1/20 | 0.43 |
| ▸ | ME3 | Q16798 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212452 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA | |
| SCHEMBL19212298 | 0.82 | TAAR1 (0.49) | SMN1; SMN2MAPTNPC1ALDH1A1GAA | |
| SCHEMBL21457821 | 0.78 | NAMPT (0.53) | SMN1; SMN2MAPTNPC1ALDH1A1GAA | |
| SCHEMBL19210942 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTNPC1ALDH1A1GAA | |
| SCHEMBL29939233 | 0.76 | ALDH1A1 (0.53) | SMN1; SMN2MAPTNPC1ALDH1A1GAA | |
| SCHEMBL19212222 | 0.76 | ME2 (0.50) | SMN1; SMN2MAPTNPC1ALDH1A1GAA | |
| SCHEMBL29939249 | 0.75 | MAPT (0.61) | SMN1; SMN2MAPTNPC1ALDH1A1GAA | |
| SCHEMBL1136936 | 0.74 | CHKA (0.54) | MAPTALDH1A1LMNAME2ME1 | |
| SCHEMBL13505609 | 0.73 | CNR1 (0.47) | SMN1; SMN2MAPTNPC1ALDH1A1CNR1 | |
| SCHEMBL5807537 | 0.73 | HDAC3 (0.60) | SMN1; SMN2NPC1ALDH1A1GAATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |