Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24641731 | 0.84 | MAPT (0.54) | MEN1KMT2ANPSR1GAAMAPT | |
| SCHEMBL28695496 | 0.83 | ME2 (0.60) | MEN1KMT2ANPSR1CA1CA2 | |
| SCHEMBL19211095 | 0.83 | MEN1 (0.56) | MEN1KMT2ANPSR1CA1CA2 | |
| SCHEMBL9727540 | 0.83 | NPSR1 (0.68) | MEN1KMT2ANPSR1CA1CA2 | |
| Hydrochloric Acid SCHEMBL19211077 | 0.82 | MEN1 (0.55) | MEN1KMT2ANPSR1CA1CA2 | |
| SCHEMBL28706501 | 0.82 | TMEM97 (0.55) | MEN1KMT2ANPSR1CA1CA2 | |
| SCHEMBL29939249 | 0.82 | MAPT (0.61) | MEN1KMT2AGAAMAPTGFER | |
| SCHEMBL6132364 | 0.81 | GAA (0.69) | MEN1KMT2ANPSR1CA1CA2 | |
| SCHEMBL28995520 | 0.81 | CA1 (0.57) | MEN1KMT2ANPSR1CA1CA2 | |
| SCHEMBL19211125 | 0.81 | SIGMAR1 (0.52) | MEN1KMT2ANPSR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |