Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.54 |
| ▸ | STS | P08842 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29707387 | 1.00 | GPR119 (0.54) | GPR119STSSMN1; SMN2MAPTKDM4E | |
| SCHEMBL19212180 | 0.87 | GPR119 (0.51) | GPR119STSSMN1; SMN2MAPTKDM4E | |
| SCHEMBL29707348 | 0.87 | GPR119 (0.51) | GPR119STSSMN1; SMN2MAPTKDM4E | |
| SCHEMBL28697178 | 0.87 | GPR119 (0.49) | GPR119STSMAPTTP53CNR1 | |
| SCHEMBL19212385 | 0.84 | STS (0.46) | GPR119STSSMN1; SMN2MAPTKDM4E | |
| SCHEMBL29707368 | 0.84 | STS (0.46) | GPR119STSSMN1; SMN2MAPTKDM4E | |
| SCHEMBL17825455 | 0.82 | GPR119 (0.62) | GPR119SMN1; SMN2MAPTKDM4ETHRB | |
| SCHEMBL4786221 | 0.82 | CNR1 (0.56) | STSSMN1; SMN2MAPTKDM4ETHRB | |
| SCHEMBL28673691 | 0.81 | GPR119 (0.49) | GPR119STSSMN1; SMN2MAPTKDM4E | |
| SCHEMBL17398495 | 0.81 | ESR2 (0.52) | GPR119STSSMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |