Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 14/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | HRH2 | P25021 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212187 | 0.86 | SIGMAR1 (0.46) | SIGMAR1TMEM97HTR1AADRA2CHRH2 | |
| SCHEMBL28681451 | 0.86 | SIGMAR1 (0.46) | SIGMAR1TMEM97 | |
| SCHEMBL21591743 | 0.84 | SIGMAR1 (0.48) | SIGMAR1TMEM97HTR1AADRA2CHRH2 | |
| SCHEMBL19211125 | 0.84 | SIGMAR1 (0.52) | SIGMAR1TMEM97HTR1AADRA2CHRH2 | |
| SCHEMBL28258183 | 0.82 | FAAH (0.42) | SIGMAR1TMEM97 | |
| Piperazine SCHEMBL28256695 | 0.82 | FAAH (0.41) | SIGMAR1TMEM97 | |
| SCHEMBL22957578 | 0.80 | ACACB (0.42) | — | |
| SCHEMBL19211083 | 0.77 | SMN1; SMN2 (0.52) | SIGMAR1 | |
| SCHEMBL28698227 | 0.77 | MAPT (0.48) | SIGMAR1 | |
| SCHEMBL16399970 | 0.76 | HTT (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |