Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | USP25 | Q9UHP3 | 4/20 | 0.39 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28256695 | 0.99 | FAAH (0.41) | FAAHACACBACACAUSP25USP28 | |
| SCHEMBL22957578 | 0.88 | ACACB (0.42) | FAAHACACBACACAUSP25USP28 | |
| SCHEMBL28256703 | 0.85 | FAAH (0.46) | FAAHUSP25USP28SIGMAR1 | |
| SCHEMBL19212437 | 0.82 | SIGMAR1 (0.48) | SIGMAR1TMEM97 | |
| SCHEMBL29707354 | 0.79 | FAAH (0.46) | FAAHACACBACACAUSP25SIGMAR1 | |
| SCHEMBL22957491 | 0.79 | FAAH (0.46) | FAAHACACBACACAUSP25SIGMAR1 | |
| SCHEMBL28258242 | 0.78 | USP28 (0.46) | FAAHACACBACACAUSP25USP28 | |
| SCHEMBL19212208 | 0.76 | USP25 (0.46) | FAAHUSP25USP28ASAH1HTR6 | |
| SCHEMBL28681451 | 0.76 | SIGMAR1 (0.46) | SIGMAR1TMEM97 | |
| SCHEMBL28258209 | 0.74 | DRD2 (0.47) | FAAHUSP25USP28NQO2TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071560-A | Thienopyridine formamide as ubiquitin-specific protease inhibitor | 福马治疗股份有限公司 | 2018-12-21 | — | — | CN | disclosed |