Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17723964 | 0.81 | CYP11B1 (0.72) | MAOBCYP11B1CYP11B2TRPM8 | |
| SCHEMBL19212930 | 0.81 | CYP11B1 (0.69) | MAOBCYP11B1CYP11B2RAB9ANR4A2 | |
| SCHEMBL19212925 | 0.76 | CYP11B1 (0.49) | CYP11B1CYP11B2F2 | |
| SCHEMBL10434802 | 0.76 | SGMS2 (0.57) | SGMS2NPC1RAB9AHTTL3MBTL1 | |
| SCHEMBL1647357 | 0.75 | FOLH1 (0.62) | MAOBL3MBTL1FOLH1 | |
| SCHEMBL19212981 | 0.74 | CYP11B1 (0.67) | CYP11B1CYP11B2L3MBTL1 | |
| SCHEMBL403151 | 0.73 | MAOB (1.00) | MAOBARRAB9AL3MBTL1GAA | |
| SCHEMBL11583825 | 0.73 | SGMS2 (0.56) | SGMS2NPC1HTTL3MBTL1GAA | |
| SCHEMBL27723974 | 0.72 | SGMS2 (0.59) | SGMS2NPC1HTTL3MBTL1GAA | |
| SCHEMBL10346925 | 0.72 | SGMS2 (0.62) | SGMS2NPC1HTTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790217-B2 | Pyridinyloxy- and phenyloxy-pyrazolyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170226097-A1 | PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226097-A1 | PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | PDXK, PNPO, PAH | MAOB 450/4885CYP11B1 84/4885CYP11B2 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.