Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 10/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.45 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824951 | 0.81 | HSD17B1 (0.48) | HSD17B1HSD17B2CYP3A4SRCCYP2C9 | |
| SCHEMBL2585790 | 0.81 | MAP4K4 (0.49) | CYP3A4MKNK2MAP4K4CA12ALDH1A1 | |
| SCHEMBL4911450 | 0.80 | PARP1 (0.43) | HSD17B1HSD17B2CYP3A4SRCCYP2C9 | |
| SCHEMBL4283341 | 0.79 | HSD17B1 (0.45) | HSD17B1HSD17B2CYP3A4SRCCYP2C9 | |
| SCHEMBL4285032 | 0.79 | HSD17B1 (0.45) | HSD17B1HSD17B2CYP3A4SRCCYP2C9 | |
| SCHEMBL4275992 | 0.79 | HSD17B1 (0.50) | HSD17B1HSD17B2CYP3A4SRCCYP2C9 | |
| SCHEMBL4288525 | 0.79 | HSD17B1 (0.45) | HSD17B1HSD17B2CYP3A4SRCCYP2C9 | |
| SCHEMBL8490974 | 0.78 | PRKCI (0.44) | LIMK1LRRK2ADORA1MTOR | |
| SCHEMBL7393282 | 0.77 | ALDH1A1 (0.50) | CYP3A4CLK4DYRK1BMAP4K4FGFR1 | |
| SCHEMBL4279339 | 0.75 | HSD17B1 (0.41) | HSD17B1HSD17B2CYP3A4SRCCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357911-B1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | AKEBIA THERAPEUTICS INC (US) | 2022-05-11 | — | — | EP | disclosed |
| EP-3357911-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3323807-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-2327696-A1 | Prolyl hydroxylase inhibitors and methods of use | Warner Chilcott Company, LLC (PR) | 2011-06-01 | — | — | EP | disclosed |