Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19217040 | 0.85 | ACACB (0.36) | PIK3CAMTORPIK3CGPARP1PARP2 | |
| SCHEMBL19217039 | 0.84 | ACACB (0.37) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL16613103 | 0.84 | PIK3CA (0.49) | PIK3CAPIK3R1MTORCCNE1CDK2 | |
| SCHEMBL19216878 | 0.82 | PIK3CA (0.56) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL16611524 | 0.82 | PIK3CA (0.60) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL19217038 | 0.76 | PIK3CA (0.43) | PIK3CAPIK3R1ALDH1A1GAAMTOR | |
| SCHEMBL16727865 | 0.74 | MTOR (0.47) | PIK3CAPIK3R1MTORPIK3CD | |
| SCHEMBL19216983 | 0.74 | ALKBH5 (0.37) | ALDH1A1 | |
| SCHEMBL16727864 | 0.72 | PIK3CA (0.56) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL16613163 | 0.68 | PIK3CA (0.68) | PIK3CAPIK3R1MTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724352-B2 | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-08 | — | — | US | disclosed |