Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19217038 | 0.84 | PIK3CA (0.43) | MTORPIK3CAPIK3CG | |
| SCHEMBL19216954 | 0.79 | PIK3CA (0.54) | MTORPIK3CAPIK3CG | |
| SCHEMBL19216914 | 0.77 | PIK3CA (0.51) | MTORPIK3CAPIK3CG | |
| SCHEMBL16611831 | 0.76 | PIK3CA (0.48) | MTORPIK3CAPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL16613115 | 0.76 | MTOR (0.48) | MTORPIK3CA | |
| SCHEMBL19217040 | 0.70 | ACACB (0.36) | MTORPIK3CAPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL19217042 | 0.70 | PIK3CA (0.34) | MTORPIK3CAPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL16611830 | 0.68 | TAAR1 (0.35) | — | |
| SCHEMBL16611805 | 0.65 | PIK3CA (0.54) | MTORPIK3CAPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL16610955 | 0.65 | PIK3CA (0.49) | MTORPIK3CAPIK3CGMAPK14CSNK1G1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724352-B2 | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-08 | — | — | US | disclosed |