Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921251 | 0.84 | PLA2G2A (0.47) | PLA2G2AALDH1A1MPOKMT2AMAPT | |
| SCHEMBL1921689 | 0.81 | IP6K1 (0.48) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL13984695 | 0.79 | NPC1 (0.44) | ALDH1A1HSP90AA1MPOMAPTRAB9A | |
| SCHEMBL1920882 | 0.77 | ELANE (0.37) | PLA2G2AMDM2CHEK1AURKACSNK1A1 | |
| SCHEMBL1921321 | 0.75 | MPO (0.50) | ALDH1A1MPOKMT2ARAB9ANPC1 | |
| SCHEMBL28748682 | 0.74 | MPO (0.45) | PLA2G2AALDH1A1LMNAMPOKMT2A | |
| SCHEMBL1921325 | 0.73 | CCNC (0.42) | CDK8ALDH1A1LMNANPSR1 | |
| SCHEMBL1921521 | 0.73 | ALDH1A1 (0.44) | PLA2G2AALDH1A1LMNAMPOMAPT | |
| SCHEMBL1921363 | 0.73 | CHEK1 (0.50) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1921320 | 0.72 | ALDH1A1 (0.54) | ALDH1A1MPOKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170833-B1 | A TRANSITION METAL CATALYZED SYNTHESIS OF 2H-INDAZOLES | SANOFI AVENTIS (FR) | 2011-06-01 | — | — | EP | claimed |