Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21746615 | 0.86 | LRRK2 (0.32) | FFAR1 | |
| SCHEMBL13127914 | 0.85 | FFAR1 (0.33) | FFAR1 | |
| SCHEMBL15292346 | 0.84 | FFAR1 (0.47) | PDK2FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21746173 | 0.83 | L3MBTL1 (0.30) | — | |
| SCHEMBL19267190 | 0.82 | PSMB1 (0.34) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL3401064 | 0.81 | ERN1 (0.30) | — | |
| SCHEMBL12179505 | 0.81 | ACHE (0.43) | PDK2FFAR1 | |
| SCHEMBL12332954 | 0.81 | FFAR1 (0.36) | FFAR1 | |
| SCHEMBL15885009 | 0.80 | HRH3 (0.34) | — | |
| SCHEMBL15504543 | 0.80 | S1PR1 (0.36) | FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864318-B1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1R KINASE INHIBITORS | MACROPHAGE PHARMA LTD (GB) | 2017-08-09 | — | — | EP | disclosed |