SCHEMBL19219070

SCHEMBL19219070

c1cc(-c2ccc(-c3ccncc3)cc2)c2nsnc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.46
▸ KDM4E B2RXH2 5/20 0.46
▸ HSD17B10 Q99714 3/20 0.46
▸ HIF1A Q16665 1/20 0.46
▸ TXNRD1 Q16881 1/20 0.40
▸ TXNRD3 Q86VQ6 1/20 0.40
▸ TXNRD2 Q9NNW7 1/20 0.40
▸ LMNA P02545 4/20 0.38
▸ NOTUM Q6P988 1/20 0.38
▸ ALDH1A1 P00352 6/20 0.37
▸ POLB P06746 1/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ PIK3CD O00329 1/20 0.37
▸ MEN1 O00255 5/20 0.36
▸ KMT2A Q03164 5/20 0.36
▸ USP2 O75604 2/20 0.36
▸ PIK3CA P42336 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30599258 0.96 KDM4E (0.48) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL29903995 0.86 MAPT (0.48) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL2605854 0.82 KDM4E (0.52) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL29004068 0.81 MAPT (0.51) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL2602433 0.81 MAPT (0.51) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL28664956 0.81 MAPT (0.56) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL198065 0.79 MAPT (0.61) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL20703588 0.78 MAPT (0.49) MAPTKDM4EHSD17B10HIF1ATXNRD1
SCHEMBL14972675 0.77 MAPT (0.46) MAPTKDM4EHSD17B10LMNANOTUM
SCHEMBL25475506 0.77 MAPT (0.43) MAPTKDM4EHSD17B10HIF1ATXNRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9932522-B2 Electrochromic compound, electrochromic composition, display element, and dimming element RICOH COMPANY, LTD. (JP) 2018-04-03 — — US disclosed
US-9932522-B2 Electrochromic compound, electrochromic composition, display element, and dimming element RICOH COMPANY, LTD. (JP) 2018-04-03 — — US disclosed
US-20170226413-A1 ELECTROCHROMIC COMPOUND, ELECTROCHROMIC COMPOSITION, DISPLAY ELEMENT, AND DIMMING ELEMENT RICOH COMPANY, LTD. (JP) 2017-08-10 — — US disclosed
US-20170226413-A1 ELECTROCHROMIC COMPOUND, ELECTROCHROMIC COMPOSITION, DISPLAY ELEMENT, AND DIMMING ELEMENT RICOH COMPANY, LTD. (JP) 2017-08-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170226413-A1 ELECTROCHROMIC COMPOUND, ELECTROCHROMIC COMPOSITION, DISPLAY ELEMENT, AND DIMMING ELEMENT EMC2, EMC1, KCNB2 MAPT 4571/4885KDM4E 2184/4885HSD17B10 2327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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