Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | FLT4 | P35916 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394139 | 0.83 | ALDH1A1 (0.46) | ALDH1A1ALKGAAMAPTFLT3 | |
| SCHEMBL27307246 | 0.78 | GAA (0.44) | ALDH1A1ALKGAAMAPTFLT3 | |
| SCHEMBL11584471 | 0.73 | ALDH1A1 (0.52) | ALDH1A1ALKGAACYP1A2CYP3A4 | |
| SCHEMBL71362 | 0.70 | NOTUM (0.48) | ALDH1A1GAACYP1A2CYP3A4NOTUM | |
| SCHEMBL5513393 | 0.70 | ALDH1A1 (0.63) | ALDH1A1MAPTCYP1A2CYP3A4NOTUM | |
| SCHEMBL7059773 | 0.69 | RAB9A (0.42) | ALDH1A1ALKGAAMAPTFLT3 | |
| SCHEMBL30630152 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MAPTCYP1A2CYP3A4NOTUM | |
| SCHEMBL27774758 | 0.68 | ALDH1A1 (0.47) | ALDH1A1ALKGAAMAPTCYP1A2 | |
| SCHEMBL27474631 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MAPTCYP1A2CYP3A4NOTUM | |
| SCHEMBL7717391 | 0.68 | ALDH1A1 (0.34) | ALDH1A1ALKFLT3FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3037419-B1 | COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES | BOSTON BIOMEDICAL INC (US) | 2019-09-04 | — | — | EP | disclosed |
| US-20180022743-A1 | COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES | BOSTON BIOMEDICAL INC (US) | 2018-01-25 | — | — | US | disclosed |
| US-9725444-B2 | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases | BOSTON BIOMEDICAL, INC (US) | 2017-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022743-A1 | COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES | CILK1, MKNK1, MKNK2 | ALDH1A1 2633/4885ALK 2084/4885GAA 2635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.