Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 6/20 | 0.67 |
| ▸ | USP8 | P40818 | 4/20 | 0.67 |
| ▸ | OTUB1 | Q96FW1 | 4/20 | 0.67 |
| ▸ | USP2 | O75604 | 3/20 | 0.67 |
| ▸ | USP36 | Q9P275 | 3/20 | 0.67 |
| ▸ | USP19 | O94966 | 2/20 | 0.65 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.65 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.63 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968066 | 0.83 | USP1 (0.77) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL29493043 | 0.81 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL19198053 | 0.81 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL29629184 | 0.79 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL7808226 | 0.79 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL29629183 | 0.79 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL19220488 | 0.77 | USP1 (0.66) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL7815859 | 0.77 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL31276578 | 0.77 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL7808410 | 0.77 | USP1 (0.77) | USP1USP8OTUB1USP2USP36 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725425-B1 | Compounds and methods for treating cancer | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-08-08 | — | — | US | disclosed |