Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 6/20 | 0.66 |
| ▸ | USP8 | P40818 | 4/20 | 0.66 |
| ▸ | OTUB1 | Q96FW1 | 4/20 | 0.66 |
| ▸ | USP2 | O75604 | 3/20 | 0.66 |
| ▸ | USP36 | Q9P275 | 3/20 | 0.66 |
| ▸ | USP19 | O94966 | 2/20 | 0.63 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.63 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812967 | 0.84 | USP1 (0.71) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL7968066 | 0.82 | USP1 (0.77) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL29493043 | 0.80 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL19198053 | 0.80 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL19220486 | 0.79 | USP1 (0.82) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL29629184 | 0.78 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL7808226 | 0.78 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL29629183 | 0.78 | USP1 (1.00) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL19220487 | 0.77 | USP1 (0.67) | USP1USP8OTUB1USP2USP36 | |
| SCHEMBL7808410 | 0.76 | USP1 (0.77) | USP1USP8OTUB1USP2USP36 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725425-B1 | Compounds and methods for treating cancer | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-08-08 | — | — | US | disclosed |