SCHEMBL1922083

SCHEMBL1922083

C=C(C#N)C(=O)OCC(F)(F)C(F)F

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
TSHR P16473 3/20 0.50
POLB P06746 2/20 0.34
GAA P10253 1/20 0.34
KMT2A Q03164 4/20 0.33
NPSR1 Q6W5P4 3/20 0.33
MEN1 O00255 3/20 0.33
LMNA P02545 2/20 0.33
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 2/20 0.32
KDM4E B2RXH2 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MAPT P10636 1/20 0.31
HTT P42858 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL447489 0.82 ALDH1A1 (0.57) ALDH1A1TSHRHTT
SCHEMBL13415386 0.81 TSHR (0.45) ALDH1A1TSHRTDP1KDM4EMAPT
SCHEMBL906288 0.79 ALDH1A1 (0.53) ALDH1A1TSHR
SCHEMBL2526807 0.78 TSHR (0.37) ALDH1A1TSHRPOLBGAAKMT2A
SCHEMBL4579850 0.77 ALDH1A1 (0.61) ALDH1A1TSHRMAPK1SMN1; SMN2
SCHEMBL5667653 0.77 TSHR (0.36) ALDH1A1TSHRPOLBGAAKMT2A
SCHEMBL7169915 0.77 TSHR (0.39) ALDH1A1TSHRPOLBGAAKMT2A
SCHEMBL227643 0.77 TSHR (0.47) ALDH1A1TSHRPOLBGAAKMT2A
SCHEMBL13239394 0.74 TSHR (0.57) ALDH1A1TSHR
SCHEMBL15762884 0.74 ALDH1A1 (0.62) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110283538-A A kind of identifiable instant drying adhesive and preparation method thereof 上海康达化工新材料股份有限公司 2019-09-27 CN claimed
CN-110283538-A A kind of identifiable instant drying adhesive and preparation method thereof 上海康达化工新材料股份有限公司 2019-09-27 CN disclosed
EP-2961807-B1 HOT MELT ADHESIVE COMPRISING CYANOACRYLATE CURING COMPOUNDS HENKEL AG & CO KGAA (DE) 2018-08-08 EP disclosed
EP-2328987-B1 TRANSFERABLE CURABLE NON-LIQUID FILM ON A RELEASE SUBSTRATE Henkel IP & Holding GmbH (DE) 2018-02-21 EP disclosed
CN-105189679-A Hot melt adhesive comprising cyanoacrylate curing compounds HENKEL AG & CO KGAA 2015-12-23 CN disclosed
US-9096778-B2 Cyanoacrylate adhesive with improved water resistance Henkel IP & Holding GmbH (DE) 2015-08-04 US disclosed
CN-103476885-B Cyanoacrylate adhesive with improved water resistance HENKEL IP HOLDING LTD 2015-06-10 CN disclosed
CN-102369252-B Transferable curable non-liquid films on release substrates LOCTITE R & D LTD 2015-03-11 CN disclosed
US-8877868-B2 Hot melt adhesive comprising cyanoacrylate curing compounds Henkel IP & Holding GmbH (DE) 2014-11-04 US disclosed
US-20140238603-A1 HOT MELT ADHESIVE COMPRISING CYANOACRYLATE CURING COMPOUNDS HENKEL AG & CO. KGAA (DE) 2014-08-28 US disclosed
US-20060233731-A1 Use, for the cosmetic treatment of keratin materials, of a film-forming composition comprising an electrophilic monomer and a non-silicone polymer, conferring a soft coating L'OREAL S.A. (FR) 2006-10-19 US disclosed
US-20060179587-A1 Dyeing composition comprising a specific pigment and at least one electrophilic monomer L'OREAL S.A. (FR) 2006-08-17 US disclosed
US-20060088488-A1 Dyeing composition comprising a mixture of at least one pigment and at least one electrophilic monomer L'OREAL S.A. (FR) 2006-04-27 US disclosed
US-20030175229-A1 Electrophilic monomers for treating the hair L'OREAL (FR) 2003-09-18 US disclosed
EP-0470722-B1 Novel alpha-cyanoacrylate and adhesive composition THREE BOND CO LTD (JP) 1994-03-02 EP disclosed
US-5290838-A Nonwhitening cyanoacrylate copolymers THREE BOND CO., LTD. (JP) 1994-03-01 US disclosed
US-5175337-A Heat resistant adhesives for quick strong bonds THREE BOND CO., LTD. (JP) 1992-12-29 US disclosed
US-5140084-A Heat resistant, high strength adhesives THREE BOND CO., LTD. (JP) 1992-08-18 US disclosed
EP-0470722-A1 Novel alpha-cyanoacrylate and adhesive composition THREE BOND CO., LTD. (JP) 1992-02-12 EP disclosed
EP-0459617-A1 Novel silicon containing alpha-cyanoacrylates THREE BOND CO., LTD. (JP) 1991-12-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060233731-A1 Use, for the cosmetic treatment of keratin materials, of a film-forming composition comprising an electrophilic monomer and a non-silicone polymer, conferring a soft coating KRT18, CUTA, VIM ALDH1A1 3279/4885TSHR 4220/4885POLB 1904/4885
US-20030175229-A1 Electrophilic monomers for treating the hair NACA, SUCLG1, TYR ALDH1A1 176/4885TSHR 4584/4885POLB 280/4885
US-20060088488-A1 Dyeing composition comprising a mixture of at least one pigment and at least one electrophilic monomer KRT18, IK, DDR1 ALDH1A1 155/4885TSHR 4653/4885POLB 1647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.