Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16433946 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL17621930 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL12597766 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL13216170 | 0.76 | ALDH1A1 (0.62) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL4037908 | 0.73 | TGFBR1 (0.56) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL13216166 | 0.71 | KDM4E (0.65) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL10242340 | 0.71 | ALOX5 (0.58) | RAB9AALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL4033819 | 0.70 | TGFBR1 (0.59) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL21565691 | 0.69 | CLK4 (0.50) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E | |
| SCHEMBL14364230 | 0.69 | HSD17B10 (0.48) | SMN1; SMN2HSD17B10RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724418-B2 | Drug combinations comprising a DGAT inhibitor and a PPAR-agonist | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-08 | — | — | US | disclosed |