Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16212418 | 0.80 | KDM4E (0.66) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27921582 | 0.77 | KDM4E (0.53) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL19222267 | 0.76 | KEAP1 (0.41) | SMN1; SMN2TDP1MAPTMEN1KMT2A | |
| SCHEMBL12419636 | 0.73 | TSHR (0.68) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL423547 | 0.69 | NPC1 (0.58) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL20219598 | 0.69 | NPC1 (0.52) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL24158897 | 0.69 | KDM4E (0.57) | KDM4ETSHRALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8816839 | 0.69 | SMN1; SMN2 (0.57) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL17694678 | 0.69 | KDM4E (0.78) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23488101 | 0.69 | KDM4E (1.00) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4289838-A2 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2023-12-13 | — | — | EP | disclosed |
| EP-3599236-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-3202461-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-3202460-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2017-08-09 | — | — | EP | disclosed |