SCHEMBL192228

SCHEMBL192228

c1cnc(SSc2ncccn2)nc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APOBEC3G Q9HC16 2/20 0.43
EHMT2 Q96KQ7 1/20 0.43
EHMT1 Q9H9B1 1/20 0.43
HSD17B10 Q99714 1/20 0.40
HDAC8 Q9BY41 2/20 0.39
HSP90AA1 P07900 2/20 0.39
MAPK1 P28482 2/20 0.36
KDM4E B2RXH2 2/20 0.35
LMNA P02545 2/20 0.35
POLB P06746 2/20 0.35
CCR1 P32246 2/20 0.35
CCR5 P51681 2/20 0.35
CCR8 P51685 2/20 0.35
HIF1A Q16665 2/20 0.35
CYP1A2 P05177 1/20 0.35
METAP1 P53582 1/20 0.35
BLM P54132 1/20 0.35
DOHH Q9BU89 1/20 0.35
P4HTM Q9NXG6 1/20 0.35
KMT2A Q03164 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11321938 0.86 EHMT2 (0.39) APOBEC3GEHMT2EHMT1HSD17B10HDAC8
SCHEMBL11319203 0.86 EHMT2 (0.39) APOBEC3GEHMT2EHMT1HSD17B10HDAC8
SCHEMBL11832740 0.85 APOBEC3G (0.35) APOBEC3GEHMT2EHMT1HSD17B10HDAC8
SCHEMBL11825510 0.85 KMT2A (0.46) APOBEC3GEHMT2EHMT1HSD17B10MAPK1
SCHEMBL10528302 0.81
SCHEMBL11446563 0.81
SCHEMBL11819786 0.79 KMT2A (0.40) APOBEC3GEHMT2EHMT1HSD17B10MAPK1
SCHEMBL11834418 0.78 HSD17B10 (0.38) APOBEC3GEHMT2EHMT1HSD17B10MAPK1
SCHEMBL11819681 0.78 EHMT2 (0.40) APOBEC3GEHMT2EHMT1HSD17B10HDAC8
SCHEMBL4135470 0.77 HSD17B10 (0.40) APOBEC3GEHMT2EHMT1HSD17B10HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119751366-A Dual-mechanism deep fungal infection resistant medicament 上海友长医药有限公司 2025-04-04 CN claimed
CN-119431313-A Antifungal compound, preparation method and application thereof 上海交通大学 2025-02-14 CN claimed
CN-119751366-A Dual-mechanism deep fungal infection resistant medicament 上海友长医药有限公司 2025-04-04 CN disclosed
CN-119431313-A Antifungal compound, preparation method and application thereof 上海交通大学 2025-02-14 CN disclosed
US-12091425-B2 Compounds that inhibit MCL-1 protein AMGEN INC. (US) 2024-09-17 US disclosed
US-20240016755-A1 METHOD FOR RAPIDLY OBTAINING ALBUMIN NANOPARTICLES LOADED WITH MAGNETIC NANOPARTICLES UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA (CL) 2024-01-18 US disclosed
US-20230365790-A1 VULCANIZED RUBBER COMPOSITION AND TIRE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-11-16 US disclosed
US-20230365790-A1 VULCANIZED RUBBER COMPOSITION AND TIRE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-11-16 US disclosed
US-11760864-B2 Trisulfide compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-09-19 US disclosed
US-11760864-B2 Trisulfide compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-09-19 US disclosed
CN-116685354-A Method for rapidly obtaining albumin nanoparticles loaded with magnetic nanoparticles 费德里科·圣玛利亚技术大学 2023-09-01 CN disclosed
US-5079305-A Improved cure rate, scorch delay and reversion resistance MONSANTO COMPANY (US) 1992-01-07 US disclosed
EP-0417057-A2 Heterocyclic thiol-based sulfenimide compounds and rubber compositions containing them MONSANTO COMPANY (US) 1991-03-13 EP disclosed
EP-0248932-B1 PROCESS FOR PREPARING POLYAMIDES Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1991-01-09 EP disclosed
US-4754016-A Process for preparing polyamide with organic phosphine/organic disulfide mixture condensing agent ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1988-06-28 US disclosed
EP-0051234-B1 A PROCESS FOR THE PRODUCTION OF A 2-AZETIDINONE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1985-03-13 EP disclosed
EP-0051234-A1 A process for the production of a 2-azetidinone derivative ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1982-05-12 EP disclosed
US-4303765-A PEPTIZATION WITH AROMATIC POLYSULFIDE BAYER AKTIENGESELLSCHAFT (DE) 1981-12-01 US disclosed
EP-0022634-A1 Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them TEIJIN LIMITED (JP) 1981-01-21 EP disclosed
US-3937718-A CARBOXYLIC ACIDS, ALCOHOLS, TERTIERY PHOSPHINES, DISULFIDES, SULFENIC ACID ESTER SANKYO COMPANY LIMITED (JA) 1976-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11760864-B2 Trisulfide compound TST, TMT1A, SULT1A1 APOBEC3G 2686/4885EHMT2 1740/4885EHMT1 1571/4885
US-12091425-B2 Compounds that inhibit MCL-1 protein MCL1, BCL9, BCL2L1 APOBEC3G 3534/4885EHMT2 3337/4885EHMT1 2231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.