Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 2/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 8/20 | 0.51 |
| ▸ | WNT3A | P56704 | 8/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492979 | 0.82 | CTNNB1 (0.56) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| SCHEMBL826046 | 0.79 | HTR1B (0.59) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| SCHEMBL12020481 | 0.79 | HTR1B (0.63) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| SCHEMBL7945108 | 0.78 | TP53 (0.50) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| Hydrochloric Acid SCHEMBL30164255 | 0.77 | HTR1B (0.61) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| Hydrochloric Acid SCHEMBL29696055 | 0.77 | HTR1B (0.57) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| SCHEMBL14880251 | 0.77 | HTR1B (0.56) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| SCHEMBL13516717 | 0.77 | CTNNB1 (0.61) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| SCHEMBL30791009 | 0.77 | CTNNB1 (0.61) | TAS1R3TAS1R1HTR1BCTNNB1WNT3A | |
| SCHEMBL5848364 | 0.76 | NPC1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994203-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-09 | — | — | US | disclosed |
| EP-2328902-A1 | PYRAZOLO [5,1-B]OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | Novartis AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010015628-A1 | PYRAZOLO [5,1-B] OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |
| US-20100035874-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035874-A1 | Organic compounds | CRH, CRHR1, CRHR2 | TAS1R3 906/4885TAS1R1 567/4885HTR1B 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.