Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11996397 | 0.82 | TDP1 (0.48) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL1922533 | 0.75 | TDP1 (0.44) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL11069630 | 0.75 | TDP1 (0.57) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL28619341 | 0.75 | TDP1 (0.58) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL1535885 | 0.72 | LTA4H (0.44) | TDP1MEN1KMT2AHPGDMAPT | |
| SCHEMBL8124330 | 0.69 | LTA4H (0.41) | TDP1MEN1KMT2AHPGDMAPT | |
| SCHEMBL11048022 | 0.67 | TDP1 (0.51) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL10883530 | 0.67 | TDP1 (0.71) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL11076466 | 0.67 | TDP1 (0.51) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL11734899 | 0.67 | MEN1 (0.48) | TDP1MEN1KMT2ATTRALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-B1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-01 | — | — | EP | disclosed |