Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15777787 | 0.78 | RIPK1 (0.36) | RIPK1PARP15PARP10SCN9APARP2 | |
| SCHEMBL17433284 | 0.75 | THRA (0.44) | PARP15PARP10THRATHRBCGAS | |
| SCHEMBL16094136 | 0.75 | THRA (0.38) | PARP15PARP10THRATHRBCGAS | |
| SCHEMBL983839 | 0.73 | TDP1 (0.47) | RIPK1TDP1PARP15PARP10PDE4A | |
| SCHEMBL19225518 | 0.72 | SCN9A (0.36) | RIPK1TDP1SCN9APDE4APDE4B | |
| SCHEMBL17418122 | 0.70 | SCN9A (0.37) | RIPK1SCN9APDE4APDE4BPDE4C | |
| SCHEMBL17433301 | 0.70 | SCN9A (0.39) | RIPK1SCN9A | |
| SCHEMBL17418124 | 0.70 | SCN9A (0.37) | RIPK1SCN9APDE4APDE4BPDE4C | |
| SCHEMBL981768 | 0.70 | RIPK1 (0.53) | RIPK1TDP1PDE4APDE4BPDE4C | |
| SCHEMBL981699 | 0.69 | TDP1 (0.46) | RIPK1TDP1PARP15PARP10PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928867-B1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN LA ROCHE (CH) | 2017-08-09 | — | — | EP | disclosed |