Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 13/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | CFD | P00746 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19225889 | 0.89 | F2 (0.40) | F2PRSS1CFDITGB1ITGA4 | |
| SCHEMBL19225883 | 0.89 | F2 (0.42) | F2PRSS1CFDCHRM3PREP | |
| SCHEMBL19225885 | 0.88 | CFD (0.42) | F2PRSS1CFDPREP | |
| SCHEMBL15602277 | 0.86 | CFD (0.40) | CFD | |
| SCHEMBL15602100 | 0.85 | F2 (0.45) | F2PRSS1CFDITGB1ITGA4 | |
| SCHEMBL19226058 | 0.83 | CFD (0.40) | F2PRSS1CFDITGB1ITGA4 | |
| SCHEMBL15599954 | 0.82 | F2 (0.42) | F2PRSS1CFDITGB1ITGA4 | |
| SCHEMBL19225842 | 0.82 | DPP4 (0.47) | PREPFAPDPP8DPP9 | |
| SCHEMBL19225882 | 0.81 | CFD (0.40) | F2CFDFAP | |
| SCHEMBL19225827 | 0.79 | CFD (0.40) | F2CFDDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |