Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 6/20 | 0.40 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 4/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19225882 | 0.89 | CFD (0.40) | CFDNTMT1F2TACR1ACE | |
| SCHEMBL19225883 | 0.83 | F2 (0.42) | CFDF2DPP8 | |
| SCHEMBL19225888 | 0.82 | CFD (0.38) | CFDNTMT1TACR1ACEMEN1 | |
| SCHEMBL19225860 | 0.82 | CFD (0.36) | CFDF2 | |
| SCHEMBL19225842 | 0.80 | DPP4 (0.47) | DPP4DPP8ACE | |
| SCHEMBL19225829 | 0.79 | CFD (0.41) | CFDF2DPP4 | |
| SCHEMBL19225834 | 0.79 | F2 (0.40) | CFDF2DPP8 | |
| SCHEMBL15602022 | 0.78 | CFD (0.42) | CFD | |
| SCHEMBL19225889 | 0.78 | F2 (0.40) | CFDF2DPP8 | |
| SCHEMBL15597282 | 0.76 | CFD (0.42) | CFDNTMT1F2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |