Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 9/20 | 0.41 |
| ▸ | HTR7 | P34969 | 9/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18967634 | 0.86 | FKBP1A (0.42) | ACE | |
| SCHEMBL15599954 | 0.83 | F2 (0.42) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL19225883 | 0.83 | F2 (0.42) | PREPFAPDPP8DPP9 | |
| SCHEMBL19225834 | 0.82 | F2 (0.40) | PREPFAPDPP8DPP9 | |
| SCHEMBL15602100 | 0.81 | F2 (0.45) | — | |
| SCHEMBL15597282 | 0.81 | CFD (0.42) | FAP | |
| SCHEMBL15597686 | 0.81 | CFD (0.43) | — | |
| SCHEMBL15607638 | 0.81 | CFD (0.56) | — | |
| SCHEMBL19225889 | 0.81 | F2 (0.40) | PREPFAPDPP8DPP9 | |
| SCHEMBL15597243 | 0.81 | CFD (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |