Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 10/20 | 0.36 |
| ▸ | DPP4 | P27487 | 5/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19225952 | 0.91 | CFD (0.41) | CFDF2DPP4KCNH2PRSS1 | |
| SCHEMBL19225891 | 0.88 | DPP4 (0.41) | CFDF2DPP4PRSS1 | |
| SCHEMBL19225838 | 0.88 | CFD (0.39) | CFDF2DPP4PRSS1 | |
| SCHEMBL19225958 | 0.87 | CFD (0.40) | CFDF2DPP4PRSS1 | |
| SCHEMBL19225883 | 0.87 | F2 (0.42) | CFDF2DPP8DPP9PRSS1 | |
| SCHEMBL19225967 | 0.84 | CFD (0.40) | CFDF2PRSS1 | |
| SCHEMBL19226064 | 0.84 | CFD (0.40) | CFDF2DPP4DPP8DPP9 | |
| SCHEMBL19225895 | 0.84 | CFD (0.40) | CFDF2PRSS1 | |
| SCHEMBL19225890 | 0.81 | CFD (0.43) | CFDF2DPP4DPP8DPP7 | |
| SCHEMBL19226078 | 0.81 | CFD (0.46) | CFDF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |