Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 4/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 8/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19225838 | 0.91 | CFD (0.39) | CFDDPP4F2PRSS1PRSS2 | |
| SCHEMBL19225883 | 0.88 | F2 (0.42) | CFDF2PRSS1 | |
| SCHEMBL19225902 | 0.87 | CFD (0.39) | CFDDPP4F2PRSS1 | |
| SCHEMBL19225891 | 0.86 | DPP4 (0.41) | CFDDPP4F2PRSS1 | |
| SCHEMBL19225895 | 0.85 | CFD (0.40) | CFDF2PRSS1 | |
| SCHEMBL19225952 | 0.85 | CFD (0.41) | CFDDPP4F2PRSS1 | |
| SCHEMBL19225967 | 0.85 | CFD (0.40) | CFDF2PRSS1 | |
| SCHEMBL19225872 | 0.85 | CFD (0.42) | CFDNPC1RAB9A | |
| SCHEMBL15602038 | 0.83 | CFD (0.40) | CFDNPC1RAB9A | |
| SCHEMBL19226064 | 0.83 | CFD (0.40) | CFDDPP4F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |