Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
| ▸ | F3 | P13726 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19159325 | 0.86 | EGFR (0.39) | CCNT1ALDH1A1MAPTPTPRCZAP70 | |
| SCHEMBL19159330 | 0.78 | SIRT2 (0.44) | MAPTKMT2AMEN1F10MRGPRX1 | |
| SCHEMBL19160071 | 0.77 | KLK1 (0.35) | CCNT1ALDH1A1MAPTZAP70SYK | |
| SCHEMBL17057610 | 0.77 | EGFR (0.37) | CCNT1ALDH1A1MAPTPTPRCZAP70 | |
| SCHEMBL5778950 | 0.75 | ADRA1A (0.38) | ALDH1A1MAPTKMT2AKCNQ4KCNQ5 | |
| SCHEMBL19160149 | 0.75 | KDM4C (0.42) | ALDH1A1 | |
| SCHEMBL15589674 | 0.74 | ADRA1A (0.40) | AGTR1ALDH1A1PTPRCKMT2ATDP1 | |
| SCHEMBL17055700 | 0.74 | KDM4E (0.38) | ALDH1A1MAPTPTPRCKMT2AMEN1 | |
| SCHEMBL17057604 | 0.73 | EGFR (0.39) | CCNT1ALDH1A1MAPTPTPRCKMT2A | |
| SCHEMBL8052745 | 0.73 | AGTR1 (0.51) | AGTR1ALDH1A1PTPRCKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |