Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273570 | 0.85 | CISD2 (0.40) | ADRA1AADRA1BEGFRALDH1A1MAPT | |
| SCHEMBL4629588 | 0.85 | EGFR (0.49) | ADRA1AADRA1BEGFRALDH1A1MAPT | |
| SCHEMBL61257 | 0.84 | KDM4E (0.41) | ADRA1AADRA1BEGFRALDH1A1MAPT | |
| SCHEMBL29238191 | 0.81 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7385926 | 0.80 | ALDH1A1 (0.41) | ADRA1AADRA1BEGFRALDH1A1MAPT | |
| SCHEMBL219602 | 0.80 | ADRA1A (0.55) | ADRA1AADRA1BALDH1A1MAPTTDP1 | |
| SCHEMBL16168119 | 0.79 | KEAP1 (0.49) | ALDH1A1MAPTKMT2AMPO | |
| SCHEMBL22164183 | 0.77 | PKM (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6715512 | 0.76 | ALDH1A1 (0.35) | ADRA1AADRA1BALDH1A1PKMNR1H2 | |
| SCHEMBL19225923 | 0.75 | CCNT1 (0.39) | ALDH1A1MAPTTDP1KMT2AKCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237874-B1 | SELECTIVE NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2006-02-22 | — | — | EP | disclosed |
| US-6635630-B2 | Respiratory system disorders; antiinflammatory agents | SCHERING CORPORATION | 2003-10-21 | — | — | US | disclosed |
| US-20030064980-A1 | Selective neurokinin antagonists | MERCK SHARP & DOHME CORP. | 2003-04-03 | — | — | US | disclosed |
| EP-1237874-A2 | SELECTIVE NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 2002-09-11 | — | — | EP | disclosed |
| US-20020123491-A1 | SELECTIVE NEUROKININ ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2002-09-05 | — | — | US | disclosed |
| US-6436928-B1 | IN COMBINATION WITH A SELECTIVE SEROTONIN REUPTAKE INHIBITOR; SUBSTITUTED CYCLIC UREAS (IMIDAZOLIDINONES); ANTAGONISTS OF TACHYKININ RECEPTORS, IN PARTICULAR AS ANTAGONISTS OF THE NEUROPEPTIDES NEUROKININ-1 RECEPTOR (NK.SUB.1). | SCHERING CORPORATION | 2002-08-20 | — | — | US | disclosed |
| WO-2001044200-A2 | SELECTIVE NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123491-A1 | SELECTIVE NEUROKININ ANTAGONISTS | CRHR1, CNR1, CRHR2 | ADRA1A 68/4885ADRA1B 82/4885GABRA1 574/4885 |
| US-20030064980-A1 | Selective neurokinin antagonists | CRHR1, CNR1, CRHR2 | ADRA1A 61/4885ADRA1B 78/4885GABRA1 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.