Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | FABP7 | O15540 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29109592 | 0.83 | TSHR (0.53) | TSHRALDH1A1FKBP1AGLAHTR2C | |
| SCHEMBL2679496 | 0.82 | TSHR (0.48) | TSHRALDH1A1FKBP1AGLAHTR2C | |
| SCHEMBL6165123 | 0.82 | TSHR (0.48) | TSHRALDH1A1FKBP1AGLAHTR2C | |
| SCHEMBL19234323 | 0.82 | TSHR (0.48) | TSHRALDH1A1FKBP1AGLAHTR2C | |
| SCHEMBL8773328 | 0.82 | TSHR (0.48) | TSHRALDH1A1FKBP1AGLAHTR2C | |
| SCHEMBL3961462 | 0.81 | KCNA5 (0.42) | TSHRALDH1A1FKBP1ACPB1KDM4E | |
| SCHEMBL3961467 | 0.81 | KCNA5 (0.42) | TSHRALDH1A1FKBP1ACPB1KDM4E | |
| SCHEMBL3961464 | 0.81 | KCNA5 (0.42) | TSHRALDH1A1FKBP1ACPB1KDM4E | |
| SCHEMBL3961461 | 0.81 | KCNA5 (0.42) | TSHRALDH1A1FKBP1ACPB1KDM4E | |
| SCHEMBL19333763 | 0.81 | KCNA5 (0.42) | TSHRALDH1A1FKBP1ACPB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |