Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922267 | 0.93 | DPP4 (0.40) | DPP4SMN1; SMN2MAPTNR2F2HTT | |
| SCHEMBL1922300 | 0.90 | DPP4 (0.42) | DPP4CYP2C9CYP2C19NPC1CRHR1 | |
| SCHEMBL1922983 | 0.79 | CRHR1 (0.40) | DPP4CYP2C9CYP2C19CRHR1DPP8 | |
| SCHEMBL1922981 | 0.79 | CRHR1 (0.40) | DPP4CYP2C9CYP2C19CRHR1DPP8 | |
| SCHEMBL1922979 | 0.77 | LMNA (0.40) | DPP4NPC1CRHR1DPP8CNR1 | |
| SCHEMBL1922297 | 0.77 | LMNA (0.48) | DPP4MAPTHTTCYP2C9CYP2C19 | |
| SCHEMBL1922992 | 0.76 | DPP4 (0.42) | DPP4CYP2C9CYP2C19NPC1CRHR1 | |
| SCHEMBL1922301 | 0.76 | DPP4 (0.44) | DPP4CYP2C9CYP2C19CRHR1DPP8 | |
| SCHEMBL1922431 | 0.74 | DPP4 (0.39) | DPP4CYP2C9CYP2C19NPC1CRHR1 | |
| SCHEMBL1922564 | 0.73 | HSD11B1 (0.41) | DPP4MAPTCRHR1DPP8HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328902-A1 | PYRAZOLO [5,1-B]OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | Novartis AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010015628-A1 | PYRAZOLO [5,1-B] OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |