Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 11/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 7/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRND | Q07001 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21364606 | 0.94 | TSHR (0.40) | SIGMAR1TSHRPDCD1LG2CD274CHRNA1 | |
| SCHEMBL24789955 | 0.92 | TSHR (0.41) | SIGMAR1TSHR | |
| SCHEMBL12317599 | 0.87 | TSHR (0.43) | SIGMAR1TSHRCDC42BPBROCK1PDCD1LG2 | |
| SCHEMBL20037915 | 0.85 | SIGMAR1 (0.46) | SIGMAR1TSHR | |
| SCHEMBL16306657 | 0.81 | KDM4E (0.38) | SIGMAR1TSHR | |
| SCHEMBL12523683 | 0.80 | SIGMAR1 (0.35) | SIGMAR1TSHRPDCD1LG2CD274CHRNA1 | |
| SCHEMBL7708635 | 0.80 | TSHR (0.43) | SIGMAR1TSHR | |
| SCHEMBL26246931 | 0.80 | TSHR (0.47) | SIGMAR1TSHRPDCD1LG2CD274CHRNB2 | |
| SCHEMBL12656466 | 0.76 | TSHR (0.40) | TSHR | |
| SCHEMBL24851626 | 0.76 | TSHR (0.47) | SIGMAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402950-A1 | SUBSTITUTED BENZIMIDAZOLES AS PAD4 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2022-12-22 | — | — | US | disclosed |
| US-20170226132-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402950-A1 | SUBSTITUTED BENZIMIDAZOLES AS PAD4 INHIBITORS | PADI4, PADI1, PADI6 | SIGMAR1 4079/4885TSHR 4041/4885CDC42BPB 2896/4885 |
| US-20170226132-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, JAK1 | SIGMAR1 1063/4885TSHR 2621/4885CDC42BPB 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.