Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC8A1 | P32418 | 10/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19230992 | 0.82 | ESR2 (0.44) | SLC8A1CHRNB2CHRNA4NOTUMESR1 | |
| SCHEMBL19230821 | 0.80 | ESR1 (0.40) | SLC8A1ESR1ESR2 | |
| SCHEMBL19230824 | 0.79 | NOTUM (0.43) | SLC8A1NOTUMRBP4 | |
| SCHEMBL19230375 | 0.79 | ESR2 (0.46) | SLC8A1CHRNB2CHRNA4NISCHESR1 | |
| SCHEMBL19230775 | 0.78 | ESR1 (0.38) | SLC8A1HSD11B1ESR1ESR2AKR1C3 | |
| SCHEMBL19230993 | 0.77 | ESR1 (0.47) | SLC8A1CHRNB2CHRNA4NISCHESR1 | |
| SCHEMBL19230656 | 0.76 | ESR1 (0.49) | CHRNB2CHRNA4NISCHKDM4EALDH1A1 | |
| SCHEMBL19230805 | 0.76 | ESR1 (0.49) | CHRNB2CHRNA4NISCHKDM4EALDH1A1 | |
| SCHEMBL19230687 | 0.76 | ESR1 (0.46) | SLC8A1ESR1ESR2 | |
| SCHEMBL19230310 | 0.76 | ESR1 (0.49) | CHRNB2CHRNA4NISCHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602811-B | FXR receptor agonists | 轩竹生物科技有限公司 | 2021-11-16 | — | — | CN | disclosed |
| WO-2017133521-A1 | FXR RECEPTOR AGONIST | 山东轩竹医药科技有限公司 | 2017-08-10 | — | — | WO | disclosed |