Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.42 |
| ▸ | MERTK | Q12866 | 16/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 15/20 | 0.36 |
| ▸ | FLT3 | P36888 | 10/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 10/20 | 0.36 |
| ▸ | AXL | P30530 | 8/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16273403 | 0.71 | HRH4 (0.46) | HRH4 | |
| SCHEMBL16273407 | 0.68 | IDH1 (0.44) | HRH4MERTKTYRO3FLT3GAS6 | |
| SCHEMBL16275101 | 0.62 | IDH1 (0.35) | HRH4HRH3 | |
| SCHEMBL19881654 | 0.60 | ALDH1A1 (0.33) | — | |
| SCHEMBL1588074 | 0.59 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL1588070 | 0.59 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL24042813 | 0.59 | SYK (0.40) | FLT3 | |
| SCHEMBL17700440 | 0.58 | CHRNA7 (0.53) | HRH4HRH3 | |
| SCHEMBL19840954 | 0.57 | — | — | |
| SCHEMBL1588110 | 0.57 | HRH4 (0.65) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732087-B2 | Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-08-15 | — | — | US | disclosed |