Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.50 |
| ▸ | DRD3 | P35462 | 15/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL228867 | 1.00 | HTR2A (0.50) | HTR2ADRD3HPGDDRD2ACKR3 | |
| SCHEMBL228147 | 0.89 | ACKR3 (0.54) | HTR2ADRD3HPGDDRD2ACKR3 | |
| SCHEMBL228146 | 0.89 | ACKR3 (0.54) | HTR2ADRD3HPGDDRD2ACKR3 | |
| SCHEMBL230475 | 0.87 | DRD3 (0.60) | HTR2ADRD3DRD2 | |
| SCHEMBL225949 | 0.86 | HSD11B1 (0.47) | HTR2ADRD3DRD2ACKR3HSD11B1 | |
| SCHEMBL228931 | 0.86 | DRD2 (0.59) | HTR2ADRD3HPGDDRD2 | |
| SCHEMBL229290 | 0.85 | DRD3 (0.61) | HTR2ADRD3DRD2ACKR3 | |
| SCHEMBL227883 | 0.84 | ACKR3 (0.45) | HTR2ADRD3DRD2ACKR3 | |
| SCHEMBL230816 | 0.84 | HSD11B1 (0.49) | HTR2ADRD2ACKR3HSD11B1 | |
| SCHEMBL27758351 | 0.84 | HSD11B1 (0.49) | HTR2ADRD2ACKR3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185513-B1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | claimed |