Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 15/20 | 0.53 |
| ▸ | DRD2 | P14416 | 13/20 | 0.53 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL228147 | 1.00 | ACKR3 (0.54) | ACKR3DRD3DRD2HTR2AHTR1A | |
| SCHEMBL229290 | 0.94 | DRD3 (0.61) | ACKR3DRD3DRD2HTR2A | |
| SCHEMBL225951 | 0.90 | DRD3 (0.55) | ACKR3DRD3DRD2HTR2A | |
| SCHEMBL225952 | 0.90 | DRD3 (0.55) | ACKR3DRD3DRD2HTR2A | |
| SCHEMBL229647 | 0.90 | DRD3 (0.54) | DRD3DRD2HTR2AHTR1A | |
| SCHEMBL228867 | 0.89 | HTR2A (0.50) | ACKR3DRD3DRD2HTR2AHPGD | |
| SCHEMBL1923323 | 0.89 | HTR2A (0.50) | ACKR3DRD3DRD2HTR2AHPGD | |
| SCHEMBL228931 | 0.87 | DRD2 (0.59) | DRD3DRD2HTR2AHPGD | |
| SCHEMBL228555 | 0.86 | DRD3 (0.52) | DRD3DRD2HTR2A | |
| SCHEMBL2533762 | 0.86 | HSD11B1 (0.48) | ACKR3DRD3DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415350-B2 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120004208-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | GOBBI LUCA (CH) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004208-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HTR2A, HTR3A, HTR2C | ACKR3 1177/4885DRD3 18/4885DRD2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.