Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922849 | 0.88 | MEN1 (0.61) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12156767 | 0.86 | MAPT (0.55) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12156708 | 0.86 | KMT2A (0.70) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12156714 | 0.86 | KMT2A (0.88) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12156711 | 0.84 | MAPT (1.00) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12156732 | 0.84 | MEN1 (0.66) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12156716 | 0.82 | MEN1 (0.59) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL25865793 | 0.82 | ALDH1A1 (0.62) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12156768 | 0.82 | GFER (0.67) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1164525 | 0.81 | TRPA1 (0.54) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8049037-B2 | Sphingosine-1-phosphate (S1P) receptor antagonists and methods for use thereof | ALLERGAN, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049037-B2 | Sphingosine-1-phosphate (S1P) receptor antagonists and methods for use thereof | ALLERGAN, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049037-B2 | Sphingosine-1-phosphate (S1P) receptor antagonists and methods for use thereof | ALLERGAN, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| EP-2328863-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF | Allergan, Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010019646-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010019646-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-02-18 | — | — | WO | disclosed |
| US-20100041715-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041715-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041715-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041715-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF | S1PR1, S1PR2, S1PR3 | MAPT 4426/4885LMNA 3708/4885SMN1; SMN2 1727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.