Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 9/20 | 0.54 |
| ▸ | CA1 | P00915 | 8/20 | 0.54 |
| ▸ | CA9 | Q16790 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922849 | 0.83 | MEN1 (0.61) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1923339 | 0.82 | MAPT (0.73) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL12156708 | 0.82 | KMT2A (0.70) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL12156716 | 0.81 | MEN1 (0.59) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL12156714 | 0.79 | KMT2A (0.88) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1164665 | 0.76 | TRPA1 (0.53) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1923355 | 0.76 | MEN1 (0.69) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1164037 | 0.76 | KCNJ11 (0.55) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1923171 | 0.75 | MAPT (0.51) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1164525 | 0.74 | TRPA1 (0.54) | ALDH1A1MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624353-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2026-05-12 | — | — | US | disclosed |
| US-12624354-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2026-05-12 | — | — | US | disclosed |
| US-12570972-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2026-03-10 | — | — | US | disclosed |
| US-12509680-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2025-12-30 | — | — | US | disclosed |
| US-20250215418-A1 | METHODS AND COMPOSITIONS FOR SIMULTANEOUS EDITING OF BOTH STRANDS OF A TARGET DOUBLE-STRANDED NUCLEOTIDE SEQUENCE | THE BROAD INSTITUTE, INC. (US) | 2025-07-03 | — | — | US | disclosed |
| US-12281303-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2025-04-22 | — | — | US | disclosed |
| US-20250115901-A2 | METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES | THE BROAD INSTITUTE, INC. (US) | 2025-04-10 | — | — | US | disclosed |
| US-20240327872-A1 | METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES | THE BROAD INSTITUTE, INC. (US) | 2024-10-03 | — | — | US | disclosed |
| CN-114127285-B | Methods and compositions for editing nucleotide sequences | 布罗德研究所股份有限公司 | 2024-09-10 | — | — | CN | disclosed |
| US-20240229077-A1 | METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES | THE BROAD INSTITUTE, INC. (US) | 2024-07-11 | — | — | US | disclosed |
| US-11643652-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-11643652-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-11643652-B2 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20230090221-A1 | METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES | THE BROAD INSTITUTE, INC. (US) | 2023-03-23 | — | — | US | disclosed |
| US-20230078265-A1 | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES | THE BROAD INSTITUTE, INC. (US) | 2023-03-16 | — | — | US | disclosed |
| EP-4146804-A1 | METHODS AND COMPOSITIONS FOR SIMULTANEOUS EDITING OF BOTH STRANDS OF A TARGET DOUBLE-STRANDED NUCLEOTIDE SEQUENCE | The Broad Institute Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| US-20220356469-A1 | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES | THE BROAD INSTITUTE, INC. (US) | 2022-11-10 | — | — | US | disclosed |
| US-11447770-B1 | Methods and compositions for prime editing nucleotide sequences | THE BROAD INSTITUTE, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| WO-2022162665-A1 | SETDB1-MICROTUBULE INTERACTION AND USE THEREOF | Ariel Scientific Innovations Ltd. (IL) | 2022-08-04 | — | — | WO | disclosed |
| EP-3942042-A1 | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES | The Broad Institute, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12624354-B2 | Methods and compositions for prime editing nucleotide sequences | POLM, FEN1, SSU72 | ALDH1A1 4143/4885MEN1 4385/4885KMT2A 3423/4885 |
| US-20230090221-A1 | METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES | PRNP, CNBP, UPF1 | ALDH1A1 4592/4885MEN1 4489/4885KMT2A 3876/4885 |
| US-20250115901-A2 | METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES | RNGTT, POLRMT, POLM | ALDH1A1 4035/4885MEN1 4195/4885KMT2A 2920/4885 |
| US-12281303-B2 | Methods and compositions for prime editing nucleotide sequences | RNGTT, POLRMT, POLM | ALDH1A1 4035/4885MEN1 4195/4885KMT2A 2920/4885 |
| US-12509680-B2 | Methods and compositions for prime editing nucleotide sequences | FEN1, RNGTT, POLM | ALDH1A1 4095/4885MEN1 3726/4885KMT2A 3102/4885 |
| US-11447770-B1 | Methods and compositions for prime editing nucleotide sequences | RNGTT, POLRMT, POLM | ALDH1A1 4019/4885MEN1 4213/4885KMT2A 2878/4885 |
| US-20230078265-A1 | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES | PRNP, CNBP, TARBP1 | ALDH1A1 4583/4885MEN1 4529/4885KMT2A 3779/4885 |
| US-12624353-B2 | Methods and compositions for prime editing nucleotide sequences | RNGTT, FEN1, POLB | ALDH1A1 4301/4885MEN1 4350/4885KMT2A 2333/4885 |
| US-12570972-B2 | Methods and compositions for prime editing nucleotide sequences | RNGTT, FEN1, POLM | ALDH1A1 4297/4885MEN1 4249/4885KMT2A 3404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.