Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.37 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | PPARD | Q03181 | 5/20 | 0.36 |
| ▸ | PPARA | Q07869 | 5/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.36 |
| ▸ | TLR2 | O60603 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036564 | 1.00 | PAOX (0.50) | PAOXALDH1A1TDP1ACHECES2 | |
| SCHEMBL18966450 | 0.93 | TDP1 (0.43) | PAOXALDH1A1TDP1ACHECES2 | |
| SCHEMBL10858203 | 0.82 | — | — | |
| SCHEMBL13883527 | 0.81 | GPR84 (0.58) | ALDH1A1TDP1PPARGPPARDPPARA | |
| SCHEMBL28742477 | 0.81 | GPR84 (0.58) | ALDH1A1TDP1PPARGPPARDPPARA | |
| SCHEMBL25815473 | 0.81 | KMT2A (0.41) | ALDH1A1TDP1CES2CES1PPARG | |
| SCHEMBL3503221 | 0.81 | GPR84 (0.58) | ALDH1A1TDP1PPARGPPARDPPARA | |
| SCHEMBL25922913 | 0.79 | CES2 (0.48) | PAOXALDH1A1TDP1CES2CES1 | |
| SCHEMBL2775487 | 0.79 | PAOX (0.72) | PAOXALDH1A1TDP1ACHECES2 | |
| SCHEMBL12686704 | 0.79 | PAOX (0.72) | PAOXALDH1A1TDP1ACHECES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906595-B1 | EXENDIN-4 DERIVATIVES AS DUAL GLP1/GLUCAGON AGONISTS | SANOFI SA (FR) | 2017-08-16 | — | — | EP | disclosed |