Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ESR1 | P03372 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19236960 | 0.84 | MEN1 (0.46) | MEN1KMT2AESR1MAPTCNR1 | |
| SCHEMBL24920126 | 0.83 | KDM4E (0.44) | KMT2AESR1MAPTGAACFD | |
| SCHEMBL19236963 | 0.83 | PSEN1 (0.42) | MEN1KMT2AMAPTCNR1POLB | |
| SCHEMBL19236962 | 0.81 | MEN1 (0.41) | MEN1KMT2AESR1MAPTCNR1 | |
| SCHEMBL29357130 | 0.81 | LMNA (0.52) | MEN1KMT2AMAPTCNR1POLB | |
| SCHEMBL17026536 | 0.81 | CFD (0.40) | ESR1CFDALDH1A1 | |
| SCHEMBL17026562 | 0.78 | CFD (0.44) | KMT2AESR1CFDLMNA | |
| SCHEMBL29781678 | 0.78 | CFD (0.44) | KMT2AESR1CFDLMNA | |
| SCHEMBL19208509 | 0.76 | TSHR (0.42) | MEN1KMT2APOLBGAACFD | |
| SCHEMBL19208600 | 0.75 | TSHR (0.44) | MEN1KMT2APOLBL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136395-A1 | BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF | BIOCRYST PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |