Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920125 | 0.87 | DYRK1A (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19208522 | 0.85 | GPR119 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29781770 | 0.84 | SLC2A1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19208780 | 0.84 | SLC2A1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19236791 | 0.83 | MEN1 (0.42) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL29357130 | 0.76 | LMNA (0.52) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL19208841 | 0.74 | TDP1 (0.44) | MAPTPOLBGAATSHRALDH1A1 | |
| SCHEMBL19236962 | 0.72 | MEN1 (0.41) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL19208509 | 0.71 | TSHR (0.42) | MEN1KMT2APOLBGAATSHR | |
| SCHEMBL19208600 | 0.70 | TSHR (0.44) | MEN1KMT2APOLBL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136395-A1 | BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF | BIOCRYST PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |