Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.36 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19445276 | 0.82 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL2082916 | 0.81 | LMNA (0.38) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL5088000 | 0.81 | LMNA (0.48) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL4120625 | 0.78 | LMNA (0.34) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL14237001 | 0.77 | LMNA (0.48) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL15623963 | 0.74 | CA1 (0.46) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL14236913 | 0.71 | LMNA (0.41) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL10625734 | 0.71 | LMNA (0.50) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL10715232 | 0.70 | FABP4 (0.42) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL385724 | 0.70 | LMNA (0.55) | LMNAKMT2AMEN1THRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714648-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-08-16 | — | — | EP | disclosed |