Sugi Predict

Sugi Predict / Compounds / SCHEMBL1923920

SCHEMBL1923920

SCHEMBL1923920

Cn1nc(CBr)c2c(Cl)ncnc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE2A O00408 3/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ NR2F2 P24468 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ NOTUM Q6P988 1/20 0.35
▸ PIK3CD O00329 6/20 0.35
▸ PIK3CA P42336 6/20 0.35
▸ PIK3CB P42338 6/20 0.35
▸ PIK3CG P48736 6/20 0.35
▸ PRKDC P78527 6/20 0.35
▸ SRC P12931 6/20 0.35
▸ ABL1 P00519 5/20 0.35
▸ EGFR P00533 5/20 0.35
▸ HCK P08631 5/20 0.35
▸ MTOR P42345 5/20 0.35
▸ EPHB4 P54760 5/20 0.35
▸ KDR P35968 4/20 0.35
▸ NR3C1 P04150 5/20 0.34
▸ PI4KB Q9UBF8 2/20 0.33
▸ ADK P55263 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23580391 0.80 NR3C1 (0.38) MEN1NR2F2KMT2ANOTUMPIK3CD
SCHEMBL18642024 0.79 NR3C1 (0.40) MEN1NR2F2KMT2ANOTUMPIK3CD
SCHEMBL1923871 0.77 NOTUM (0.48) MEN1NR2F2KMT2ANOTUMPIK3CD
SCHEMBL14243160 0.75 CHEK1 (0.37) MEN1NR2F2KMT2ANOTUMPIK3CD
SCHEMBL1923568 0.73 PIK3CD (0.39) MEN1NR2F2KMT2APIK3CDPIK3CA
SCHEMBL12845037 0.71 NOTUM (0.35) MEN1NR2F2KMT2ANOTUMPIK3CD
SCHEMBL12590024 0.71 MEN1 (0.36) MEN1NR2F2KMT2ASRCADK
SCHEMBL18656780 0.70 MEN1 (0.35) MEN1NR2F2KMT2ASRCEGFR
SCHEMBL1923342 0.70 PIK3CD (0.50) MEN1NR2F2KMT2APIK3CDPIK3CA
SCHEMBL2076334 0.69 KDM4E (0.42) MEN1NR2F2KMT2ANOTUMPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968554-B2 Pyrazolo[3,4-d]pyrimidine derivatives HOFFMAN-LA ROCHE INC. (US) 2011-06-28 — — US disclosed
US-7968554-B2 Pyrazolo[3,4-d]pyrimidine derivatives HOFFMAN-LA ROCHE INC. (US) 2011-06-28 — — US disclosed
US-7968554-B2 Pyrazolo[3,4-d]pyrimidine derivatives HOFFMAN-LA ROCHE INC. (US) 2011-06-28 — — US disclosed
EP-2188290-B1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS HOFFMANN LA ROCHE (CH) 2011-06-08 — — EP disclosed
EP-2188290-A1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS F. Hoffmann-Roche AG (CH) 2010-05-26 — — EP disclosed
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BARTKOVITZ DAVID JOSEPH 2009-02-19 — — US disclosed
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BARTKOVITZ DAVID JOSEPH 2009-02-19 — — US disclosed
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BARTKOVITZ DAVID JOSEPH 2009-02-19 — — US disclosed
WO-2009021869-A1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2009-02-19 — — WO disclosed
WO-2009021869-A1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2009-02-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BRAF, RAF1, PRKDC PDE2A 1579/4885MEN1 2210/4885NR2F2 2886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.