Sugi Predict

Sugi Predict / Compounds / SCHEMBL1923871

SCHEMBL1923871

SCHEMBL1923871

Cc1nn(C)c2ncnc(Cl)c12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 1/20 0.48
▸ MEN1 O00255 1/20 0.40
▸ NR2F2 P24468 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ PIK3CD O00329 1/20 0.38
▸ ABL1 P00519 1/20 0.38
▸ EGFR P00533 1/20 0.38
▸ HCK P08631 1/20 0.38
▸ SRC P12931 1/20 0.38
▸ KDR P35968 1/20 0.38
▸ PIK3CA P42336 1/20 0.38
▸ PIK3CB P42338 1/20 0.38
▸ MTOR P42345 1/20 0.38
▸ PIK3CG P48736 1/20 0.38
▸ EPHB4 P54760 1/20 0.38
▸ PRKDC P78527 1/20 0.38
▸ PI4KB Q9UBF8 1/20 0.38
▸ NR3C1 P04150 13/20 0.38
▸ LMNA P02545 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23580391 0.84 NR3C1 (0.38) NOTUMMEN1NR2F2KMT2APIK3CD
SCHEMBL12647324 0.82 NOTUM (0.51) NOTUMPIK3CDABL1EGFRHCK
SCHEMBL14243160 0.79 CHEK1 (0.37) NOTUMMEN1NR2F2KMT2APIK3CD
SCHEMBL18642024 0.79 NR3C1 (0.40) NOTUMMEN1NR2F2KMT2APIK3CD
SCHEMBL10260251 0.78 PIK3CD (0.52) NOTUMPIK3CDABL1EGFRHCK
SCHEMBL31337205 0.77 NOTUM (0.51) NOTUMPIK3CDABL1EGFRHCK
SCHEMBL23580425 0.77 NOTUM (0.51) NOTUMPIK3CDABL1EGFRHCK
SCHEMBL1923920 0.77 PDE2A (0.37) NOTUMMEN1NR2F2KMT2APIK3CD
SCHEMBL12845037 0.75 NOTUM (0.35) NOTUMMEN1NR2F2KMT2APIK3CD
SCHEMBL13019651 0.74 YTHDC1 (0.46) NOTUMPIK3CDABL1EGFRHCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710428-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-25 — — EP disclosed
CN-115151550-B External nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) modulators and uses thereof 桑福德·伯纳姆·普雷比医学发现研究所 2024-11-22 — — CN disclosed
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-09-19 — — US disclosed
CN-112204009-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2024-05-07 — — CN disclosed
EP-3452456-B1 BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2023-07-05 — — EP disclosed
US-20230121698-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute 2023-04-20 — — US disclosed
CN-109641854-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-02-03 — — CN disclosed
EP-4081528-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute (US) 2022-11-02 — — EP disclosed
CN-115151550-A Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) modulators and uses thereof 桑福德·伯纳姆·普雷比医学发现研究所 2022-10-04 — — CN disclosed
US-20220106281-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2022-04-07 — — US disclosed
EP-2188290-B1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS HOFFMANN LA ROCHE (CH) 2011-06-08 — — EP disclosed
EP-2188290-A1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS F. Hoffmann-Roche AG (CH) 2010-05-26 — — EP disclosed
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BARTKOVITZ DAVID JOSEPH 2009-02-19 — — US disclosed
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BARTKOVITZ DAVID JOSEPH 2009-02-19 — — US disclosed
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BARTKOVITZ DAVID JOSEPH 2009-02-19 — — US disclosed
WO-2009021869-A1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2009-02-19 — — WO disclosed
WO-2009021869-A1 PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2009-02-19 — — WO disclosed
WO-2009006404-A2 HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS SUNESIS PHARMACEUTICALS, INC. (US) 2009-01-08 — — WO disclosed
US-20090005359-A1 Heterocyclic Compounds Useful as RAF Kinase Inhibitors SUNESIS PHARMACEUTICALS, INC (US) 2009-01-01 — — US disclosed
US-20090005359-A1 Heterocyclic Compounds Useful as RAF Kinase Inhibitors SUNESIS PHARMACEUTICALS, INC (US) 2009-01-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090048274-A1 PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES BRAF, RAF1, PRKDC NOTUM 3315/4885MEN1 2210/4885NR2F2 2886/4885
US-20230121698-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF ENPP1, ENPP3, PPA1 NOTUM 3644/4885MEN1 1743/4885NR2F2 4017/4885
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 NOTUM 4143/4885MEN1 4714/4885NR2F2 729/4885
US-20220106281-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 NOTUM 4143/4885MEN1 4714/4885NR2F2 729/4885
US-20090005359-A1 Heterocyclic Compounds Useful as RAF Kinase Inhibitors BRAF, RAF1, ARAF NOTUM 3496/4885MEN1 2084/4885NR2F2 2404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.