Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4004912 | 0.83 | MAPT (0.48) | GAAMAPTTDP1KDM4EGFER | |
| SCHEMBL15286061 | 0.80 | KDM4E (0.47) | GAAMAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11792172 | 0.75 | GAA (0.62) | GAAMAPTTDP1KDM4ENPC1 | |
| SCHEMBL14247246 | 0.75 | MAPT (0.58) | GAAMAPTTDP1KDM4ENPC1 | |
| SCHEMBL30711414 | 0.73 | UHRF1 (0.39) | KMT2AEGFRUHRF1 | |
| SCHEMBL1584807 | 0.73 | UHRF1 (0.39) | KMT2AEGFRUHRF1 | |
| Hydrochloric Acid SCHEMBL20266526 | 0.72 | UHRF1 (0.38) | EGFRUHRF1 | |
| SCHEMBL16657411 | 0.71 | GAA (0.58) | GAAMAPTTDP1KDM4ENPC1 | |
| SCHEMBL22701403 | 0.70 | MAPT (0.56) | GAAMAPTTDP1KDM4ENPC1 | |
| SCHEMBL21697451 | 0.70 | EGFR (0.47) | GAAMAPTTDP1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831079-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2017-08-16 | — | — | EP | disclosed |